{
  "id": 15955048,
  "title": "METTL1 gene dosage and catalytic activity define a targetable vulnerability in pediatric cancers",
  "url": "https://urgent.news/2026/10/21/mettl1-gene-dosage-and-catalytic-activity-define-a-targetable",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.20.760582v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "METTL1 is responsible for catalyzing N7-methylguanosine (m7G) methylation of tRNAs. METTL1-dependent oncogenic mechanisms include both its methyltransferase catalytic activity and, in specific instances, non-catalytic interactions that maintain aminoacylated tRNA levels in malignant cells. We show that METTL1 copy number gain and elevated expression are a feature of pediatric tumors that are…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}