{
  "id": 15879021,
  "title": "A hyperactivating mutation in formin-like 2 causes brain and vertebrae defects",
  "url": "https://urgent.news/2026/10/21/a-hyperactivating-mutation-in-formin-like-2-causes-brain-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759550v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Formins are a group of proteins that nucleate and polymerize actin monomers into filaments to promote cell morphology and migration. Mutations in formin-encoding genes cause a broad spectrum of human diseases, ranging from kidney disease to non-syndromic intellectual disability. Through a forward genetics screen, we identified a mouse strain (nmf418) with a homozygous mutation in a splice…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}