{
  "id": 15879016,
  "title": "PODXL regulates the neuronal entry of α-synuclein aggregates",
  "url": "https://urgent.news/2026/10/21/podxl-regulates-the-neuronal-entry-of-synuclein-aggregates",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759470v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Cell-to-cell transmission of -synuclein (-Syn) aggregates is a key event in Parkinson's disease (PD) pathogenesis, yet the neuronal surface factors that govern uptake of pathogenic -Syn fibrils remain undefined. We developed a flow cytometry-based CRISPR activation screen for modifiers of -Syn preformed fibril (PFF) uptake by human iPSC-derived cortical neurons. By interrogating 68 genes encoding…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}