{
  "id": 15805070,
  "title": "Dual-portal ligand transport in human cytochrome P450 17A1",
  "url": "https://urgent.news/2026/10/20/dual-portal-ligand-transport-in-human-cytochrome-p450-17a1",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-20T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.19.760170v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Human cytochrome P450 17A1 (CYP17A1) is the qualitative regulator of steroidogenesis, catalyzing both 17-hydroxylation and 17,20-lyase cleavage at a single active site, and is the target of the prostate cancer drug abiraterone. Crystal structures show an almost fully enclosed site and do not reveal how lipophilic steroids reach it from the endoplasmic reticulum membrane or how the more polar…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}