{
  "id": 15805068,
  "title": "HaloPROTAC-mediated degradation reveals SOX10-dependent gene expression changes in melanoma cells",
  "url": "https://urgent.news/2026/10/20/haloprotac-mediated-degradation-reveals-sox10-dependent-gene",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-20T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.19.760213v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The transcription factor SOX10 is required for melanoma cell proliferation. However, SOX10 expression in single cells is heterogeneous, and low SOX10-expressing cells exhibit a dormant-invasive phenotype associated with drug resistance and metastasis. Despite longstanding interest in SOX10 as a diagnostic marker and potential therapeutic target in melanoma, the molecular mechanism and targets of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}