{
  "id": 15790229,
  "title": "Combination therapy reveals potential vulnerability in aggressive osteosarcoma",
  "url": "https://urgent.news/2026/10/20/combination-therapy-reveals-potential-vulnerability-in-aggressive",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-20T19:20:19.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-combination-therapy-reveals-potential-vulnerability.html"
  },
  "original_language": "en",
  "account": "Scientists from St. Jude Children's Research Hospital have discovered a potential weakness in certain aggressive forms of osteosarcoma, a pediatric bone cancer. In a study published in the Journal of Experimental Medicine, researchers found that a combination therapy involving degradation of a protein called EP300 and inhibition of AKT, a well-known cancer drug target, slowed tumor growth and increased survival in preclinical models. This combination approach highlights the disease's clinical potential, as osteosarcoma has lower survival rates compared to many other cancers and has not seen major therapeutic improvements in the last 40 years. The study also suggests that certain mutations in osteosarcoma tumors may serve as biomarkers for sensitivity to the combination therapy.",
  "summary": "Scientists co-led by St. Jude Children's Research Hospital have identified a potential therapeutic vulnerability in some forms of osteosarcoma. A combination approach described today in the Journal of Experimental Medicine slowed tumor growth and prolonged survival in preclinical models of this pediatric bone cancer. The therapies degraded EP300 (a protein that is co-opted to express oncogenes in…",
  "key_points": [
    "Combination therapy of EP300 degradation and AKT inhibition slows osteosarcoma growth.",
    "Study published in Journal of Experimental Medicine reveals potential vulnerability.",
    "Certain tumor mutations may indicate sensitivity to the combination treatment."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}