{
  "id": 15743965,
  "title": "Added receptor helps CAR T cells stay in bone marrow in cancer mouse models",
  "url": "https://urgent.news/2026/10/20/added-receptor-helps-car-t-cells-stay-in-bone-marrow-in-cancer-mouse",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-20T13:00:01.000Z",
  "source": {
    "name": "Phys.org",
    "slug": "phys-org",
    "url": "https://phys.org/news/2026-10-added-receptor-car-cells-stay.html"
  },
  "original_language": "en",
  "account": "Researchers have discovered a new way to bolster the effectiveness of CAR T-cell therapy for bone-metastatic cancers. By engineering gamma-delta T cells to produce a receptor that recognizes RANKL, a molecule prevalent in bone and tumor environments, these cells showed enhanced retention in the bone marrow. This improvement, detailed in a study published in Cellular and Molecular Immunology, suggests that modified gamma-delta CAR T cells could maintain their presence longer in patients with bone-metastatic solid tumors.",
  "summary": "By turning a patient's own immune cells into stronger cancer-fighting cells, CAR T-cell therapy has transformed how some blood cancers are treated. But it's been harder to extend this approach to solid tumors, including cancer that has spread to the bone.",
  "key_points": [
    "Researchers engineered gamma-delta T cells to produce RANKL receptor.",
    "Modified cells showed enhanced retention in bone marrow.",
    "Study published in Cellular and Molecular Immunology."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}