{
  "id": 15735643,
  "title": "BNIP3L/NIX-mediated mitophagy limits Alzheimer disease pathology and preserves neuronal function",
  "url": "https://urgent.news/2026/10/20/bnip3l-nix-mediated-mitophagy-limits-alzheimer-disease-pathology-and",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-20T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.18.759942v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Defective mitophagy is emerging as a key contributor to Alzheimer disease (AD), but the neuronal pathways governing mitochondrial clearance and their contribution to disease progression remain poorly understood. Here, we identify BNIP3L/NIX-dependent mitophagy as a conserved neuronal quality control pathway that maintains mitochondrial fitness and constrains AD-associated proteotoxicity. Loss of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 4,
    "also_reported_by": [
      {
        "outlet": "Live Science",
        "title": "A gene variant triples the risk of getting Alzheimer's disease — fat buildup in brain cells may be to blame, study finds",
        "url": "https://urgent.news/2026/10/19/a-gene-variant-triples-the-risk-of-getting-alzheimers-disease-fat",
        "published": "2026-10-19T19:35:00.000Z"
      },
      {
        "outlet": "ScienceDaily Health",
        "title": "Scientists find a way to fight Alzheimer’s brain damage without removing toxic tau",
        "url": "https://urgent.news/2026/10/20/scientists-find-a-way-to-fight-alzheimers-brain-damage-without",
        "published": "2026-10-20T09:52:35.000Z"
      },
      {
        "outlet": "Live Science",
        "title": "A gene variant triples the risk of getting Alzheimer's disease — fat buildup in brain cells may be to blame, study finds",
        "url": "https://urgent.news/2026/10/20/a-gene-variant-triples-the-risk-of-getting-alzheimers-disease-fat",
        "published": "2026-10-20T11:02:05.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}