{
  "id": 15603901,
  "title": "Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance",
  "url": "https://urgent.news/2026/10/19/ubiquitin-ligase-rnf126-exerts-functions-in-lysosomal-damage-response",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-19T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759566v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The response to lysosomal membrane permeabilization involves extensive ubiquitylation at the lysosome; however, the ubiquitin ligases identified so far cannot account for the complexity of the response. Using extensive spatial proteomics, we identified RNF126 as a new ligase that is robustly recruited to lysosomes in response to a range of different damage triggers across distinct cell types.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}