{
  "id": 15603898,
  "title": "Arrested PPTC7 import couples mitochondrial depolarisation to NIX and BNIP3 degradation",
  "url": "https://urgent.news/2026/10/19/arrested-pptc7-import-couples-mitochondrial-depolarisation-to-nix-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-19T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759620v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mitophagy is initiated by two distinct pathways that are both coupled to mitochondrial protein import. Import stress stabilises PINK1 at the outer mitochondrial membrane, activating the Parkin and ubiquitin-dependent pathway. Receptor-mediated pathways are governed by the expression of outer mitochondrial membrane proteins NIX and BNIP3. Mitophagy is limited by their degradation, via SCFFBXL4.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}