{
  "id": 15540838,
  "title": "IL-2 and CD40L can establish and sustain a human B cell-mediated immune regulatory network",
  "url": "https://urgent.news/2026/10/18/il-2-and-cd40l-can-establish-and-sustain-a-human-b-cell-mediated",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.755729v1?rss=1"
  },
  "original_language": "en",
  "account": "The study reveals that IL-2 and CD40L can establish and sustain a human B cell-mediated immune regulatory network. The researchers discovered that these two factors enable class-switched memory (CSM) B cells to adopt an immunosuppressive phenotype. This phenotype is marked by the expression of surface TIGIT, along with other inhibitory receptors like PD-1, LAG-3, GITR, CD39, and CTLA-4. Additionally, the CSM B cells produce soluble molecules such as IL-10, granzyme B, and IL-35.\n\nTIGIT+ CSM B cells with functional CCR9 display significant impairments in total immunoglobulin secretion, yet they continue to secrete IgA2. Moreover, the ex vivo-generated TIGIT+ CSM B cells can suppress human T cell-mediated inflammation in a xenogeneic mouse model of acute graft-versus-host disease. Surprisingly, these B cells also promote an IL-10-producing regulatory T cell (Treg) response.\n\nThe findings demonstrate that IL-2/CD40L are key drivers of a B cell-mediated immune regulatory network. Notably, these factors generate TIGIT+ CSM B cells, which further enhance the Treg response. This research supports the development of TIGIT+ B cell-based therapy models for treating inflammatory diseases.",
  "summary": "B cells can control inflammation, but the factors governing B cell-mediated immune regulatory network remain unclear. We report that IL-2/CD40L enable class-switched memory (CSM) B cells to acquire an immunosuppressive phenotype characterized by the expression of surface TIGIT as well as multiple other inhibitory receptors (PD-1, LAG-3, GITR, CD39, and CTLA-4) and soluble molecules (IL-10,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}