{
  "id": 15480509,
  "title": "Spatial genomics tool maps long-range DNA interactions while preserving cells' locations within tissues",
  "url": "https://urgent.news/2026/10/18/spatial-genomics-tool-maps-long-range-dna-interactions-while",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-18T20:00:02.000Z",
  "source": {
    "name": "Phys.org",
    "slug": "phys-org",
    "url": "https://phys.org/news/2026-10-spatial-genomics-tool-range-dna.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "Scientists at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have developed a new spatial genomics tool called SpaceA that can map long-range DNA interactions while preserving the cells' locations within tissues. This technology combines microfluidic spatial barcoding and a ligation-free contact detection strategy to investigate higher-order chromatin architecture within tissue sections. The researchers applied SpaceA to nine mouse embryo sections at different developmental stages, generating approximately 4 TB of data to characterize chromatin conformation changes during embryonic development. Their findings revealed significant changes in chromatin organization, including a dramatic transition in A/B compartments and alterations in mid-range and long-range interactions. These results provide new insights into how genome architecture regulates gene expression in native cellular environments and challenge the classical model of gene expression regulation.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}