{
  "id": 15433679,
  "title": "PlasmoRhythm: A comprehensive database for malaria-associated rhythmic transcripts, proteins, and metabolites",
  "url": "https://urgent.news/2026/10/18/plasmorhythm-a-comprehensive-database-for-malaria-associated-rhythmic",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.11.758397v1?rss=1"
  },
  "original_language": "en",
  "account": "The malaria transmission cycle is intricately regulated by rhythmic processes occurring in the parasite, host, and vector. Understanding these rhythms is crucial for developing effective antimalarial interventions. However, existing time-resolved omics datasets are scattered across various species, experimental setups, and analytical tools, making it challenging to conduct comparative analysis. To address this issue, researchers have developed PlasmoRhythm, a comprehensive database that integrates 67 transcriptomic, proteomic, and metabolomic datasets from 15 studies. These datasets encompass a total of 1,126 sampling events, covering Plasmodium species, mammalian hosts, and Anopheles vectors. PlasmoRhythm offers harmonized metadata and rhythmicity outputs derived from advanced analytical tools such as JTK_CYCLE, ARSER, Lomb-Scargle, and meta2d function. These features enable interactive cross-study interrogation of molecular profiles. Dedicated modules within PlasmoRhythm allow researchers to explore rhythmic virulence factors and antimalarial drug interactors, providing a unified framework for hypothesis generation across the entire malaria transmission cycle. PlasmoRhythm is freely accessible online at https://project.iith.ac.in/cgntlab/PlasmoRhythm/.",
  "summary": "Abstract: Motivation: The malaria transmission cycle is temporally organized across three interacting biological systems: the parasite, vertebrate host, and mosquito vector. Rhythms in parasite development, host physiology, and vector behavior govern infection dynamics, transmission, and the efficacy of stage-specific antimalarial interventions. However, the molecular architecture connecting…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}