{
  "id": 15352643,
  "title": "Order Matters: Ambient RNA correction confounds doublet detection in single-cell RNA sequencing",
  "url": "https://urgent.news/2026/10/17/order-matters-ambient-rna-correction-confounds-doublet-detection-in",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758369v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "A common technical artifact in droplet-based single-cell RNA sequencing (scRNA-seq) is the capture of two cells in the same droplet, termed doublets. Doublets may present as hybrid cell types, and their removal is a critical step during quality control. Another form of contamination is ambient RNA, which originates from free floating RNA released from other cells in suspension, likely during cell…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Scientific Reports",
        "title": "Integrating bulk and single-cell RNA sequencing to identify mitochondrial quality control-related key genes in rheumatoid arthritis",
        "url": "https://urgent.news/2026/10/18/integrating-bulk-and-single-cell-rna-sequencing-to-identify",
        "published": "2026-10-18T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}