{
  "id": 151654,
  "title": "MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis",
  "url": "https://urgent.news/2026/07/27/morc2-controls-hif-1-stability-via-an-hdac4-dependent-mechanism-to",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-07-27T07:00:00.000Z",
  "source": {
    "name": "PNAS",
    "slug": "pnas",
    "url": "https://www.pnas.org/doi/abs/10.1073/pnas.2537114123?af=R"
  },
  "original_language": "en",
  "account": null,
  "summary": "Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceThis study identifies MORC2 as a crucial negative regulator of HIF-α. We define a mechanism in which MORC2 competes with HDAC4 for HIF-1α binding to govern its acetylation and stability. This competitive binding is essential for normal ...",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}