{
  "id": 150803,
  "title": "New therapy shrinks tumors to treat lung cancer",
  "url": "https://urgent.news/2026/08/04/new-therapy-shrinks-tumors-to-treat-lung-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-04T22:00:06.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-therapy-tumors-lung-cancer.html"
  },
  "original_language": "en",
  "account": "Lung cancer remains a leading cause of cancer deaths in the United States, making the need for more effective treatments critical. A research team from Stony Brook Cancer Center has developed a novel therapeutic called Gem-miR-129 that shows promise in combating drug resistance and shrinking tumors in non-small cell lung cancer (NSCLC) models. Led by Jingfang Ju, Ph.D., this multitargeted, multimodal miRNA-129-based therapy combines a naturally occurring cancer-fighting molecule with a commonly used chemotherapy drug to simultaneously shut down three oncogenic driver proteins. In lab tests, Gem-miR-129 reduced tumor burden by over 95% and increased survival time in mice by several weeks. This approach may provide a solution for NSCLC patients who develop resistance to standard treatments, such as gemcitabine and EGFR inhibitors, as it not only eliminates drug-resistant tumor cells but also enhances the activity of antitumor T cells. While the safety and efficacy of Gem-miR-129 in humans have not yet been tested, this promising development could pave the way for future clinical trials.",
  "summary": "The need for more effective lung cancer treatments is paramount, as the disease remains a leading cause of cancer deaths in the United States. New findings by a research team from the Stony Brook Cancer Center highlight a novel therapeutic shown to be highly effective in reducing non-small cell lung cancer (NSCLC) tumors and appearing to halt drug resistance in a laboratory model.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}