{
  "id": 1501187,
  "title": "HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation",
  "url": "https://urgent.news/2026/08/17/hif-1-integrates-metabolic-and-immunoregulatory-programs-in-ror-t",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.11.744213v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Regulatory T (Treg) cells expressing RORgamma-t accumulate in the intestinal mucosa, yet the signals that determine whether they remain suppressive or acquire inflammatory features are incompletely defined. We first reanalyzed human ileal single-cell data and identified Crohn's disease-enriched FOXP3+ states in which RORC, HIF1A, hypoxia-responsive, inflammatory, and metabolic programs converged.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}