{
  "id": 14961030,
  "title": "Splicing-guaranteed artificial introns enable efficient homology-directed repair at internal exons and streamlined cell engineering",
  "url": "https://urgent.news/2026/10/16/splicing-guaranteed-artificial-introns-enable-efficient-homology",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759525v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Selection-marker-assisted homology-directed repair (HDR) efficiently edits coding sequence termini but is poorly suited for internal exons. Here, we developed artificial reporter intron-based HDR (ARI-HDR), which inserts a selectable intron into target exons to enable precise internal-exon editing. Although designed for scarless removal by splicing, ARIs frequently exhibit inaccurate splicing.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}