{
  "id": 14953283,
  "title": "ARID5A Is a PERK-Dependent Effector of the Endoplasmic Reticulum Stress Response That Protects Against Steatohepatitis",
  "url": "https://urgent.news/2026/10/16/arid5a-is-a-perk-dependent-effector-of-the-endoplasmic-reticulum",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.15.759473v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Lipotoxic endoplasmic reticulum (ER) stress is a fundamental feature of metabolic dysfunction-associated steatohepatitis (MASH). ER stress activates adaptive signaling processes that aim to restore ER homeostasis. Yet, depending on the duration, magnitude, and cellular context, sustained ER stress becomes maladaptive and leads to cell death. The regulatory pathways that determine adaptive versus…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}