{
  "id": 14909162,
  "title": "Lef1 Promotes Foxi1-Dependent Ionocyte Specification by Airway Submucosal Gland Progenitors",
  "url": "https://urgent.news/2026/10/16/lef1-promotes-foxi1-dependent-ionocyte-specification-by-airway",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758987v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Pulmonary ionocytes are rare cells in submucosal gland (SMG)-containing airways thought to have specialized ion transport properties that regulate airway surface fluid and mucus composition. The origins of pulmonary ionocytes remain unclear, but their association with airway SMGs suggests they may arise from specialized progenitors in this compartment. We show that mouse glandular myoepithelial…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "bioRxiv",
        "title": "Ncf1/Igfbp2 Signaling Regulates Airway Submucosal Gland Progenitor Fitness and Ionocyte Specification",
        "url": "https://urgent.news/2026/10/15/ncf1-igfbp2-signaling-regulates-airway-submucosal-gland-progenitor",
        "published": "2026-10-15T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}