{
  "id": 1478348,
  "title": "Cryo-EM of a nucleotide-polymerizing ribozyme enables its predictive improvement",
  "url": "https://urgent.news/2026/08/17/cryo-em-of-a-nucleotide-polymerizing-ribozyme-enables-its-predictive",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.14.744467v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Ribozymes capable of self-replication from nucleotides would have been central to the hypothesized RNA World. The leading laboratory models for such molecules were converted from a class I ligase by in vitro evolution but then developed without 3D structures. Here, scaffolded cryo-EM of the substrate-free tC19Z RNA polymerase ribozyme at 3.1 [A] resolution shows how this conversion was achieved.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}