{
  "id": 14726789,
  "title": "How the biggest Alzheimer's risk gene disrupts the process of insulating neurons",
  "url": "https://urgent.news/2026/10/15/how-the-biggest-alzheimers-risk-gene-disrupts-the-process-of",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-15T15:00:12.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-biggest-alzheimer-gene-disrupts-insulating.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "One of the main ways that the APOE4 gene variant, the biggest genetic risk factor for late-onset Alzheimer's disease, undermines brain circuit function is by disrupting the process of insulating neurons with a fatty sheath that optimizes their electrical transmission.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "bioRxiv",
        "title": "Decoupling of spontaneous and evoked activity in locus coeruleus neurons: early synaptic and ion-channel remodeling in a mouse model of Alzheimer's disease",
        "url": "https://urgent.news/2026/10/15/decoupling-of-spontaneous-and-evoked-activity-in-locus-coeruleus",
        "published": "2026-10-15T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}