{
  "id": 14704954,
  "title": "What is pathogenicity? Structural vulnerabilities lead to distinct phenotypes in a membrane protein, ATP1A3",
  "url": "https://urgent.news/2026/10/15/what-is-pathogenicity-structural-vulnerabilities-lead-to-distinct",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758912v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Distinct protein features of pathogenic variants are illustrated here for a gene with an extraordinarily wide range of neurological syndromes: ATP1A3, the neuronal Na,K-ATPase. Vulnerable structure features produce mechanistically different consequences, from loss or gain of function to maladaptive cell biological responses. Variants in specific structural elements (glycines, prolines, and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}