{
  "id": 14675048,
  "title": "Mitigating genotype-driven bias improves atlas-scale single-cell DNA methylome profiling",
  "url": "https://urgent.news/2026/10/15/mitigating-genotype-driven-bias-improves-atlas-scale-single-cell-dna",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.756197v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Advances in single-cell DNA methylation profiling render cohort-level, cell-type-resolved atlasing efforts increasingly feasible. In such studies, cells from multiple individuals with distinct genotypes are often analyzed in pooled experimental designs. This creates a major analytical challenge: C-to-T variants are misinterpreted as bisulfite-conversion events, thus conflating genotype and DNA…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}