{
  "id": 14675046,
  "title": "A microbiota-driven neuroepithelial feed-forward circuit drives gastroesophageal junction tumorigenesis",
  "url": "https://urgent.news/2026/10/15/a-microbiota-driven-neuroepithelial-feed-forward-circuit-drives",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.759004v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The gastroesophageal junction (GEJ) is continuously exposed to refluxed bile acids and microbial perturbations, yet how these environmental cues are converted into persistent oncogenic signaling is unknown. Here we show that bile acid remodeling enriches the oral commensal Prevotella melaninogenica at the GEJ, where bacterial succinate activates both vagal sensory neurons and SUCNR1-expressing…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}