{
  "id": 146585,
  "title": "Aberrant protein activity rewires lymphoma cells to survive BTK inhibitors, offering target for treatment resistance",
  "url": "https://urgent.news/2026/08/04/aberrant-protein-activity-rewires-lymphoma-cells-to-survive-btk",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-04T19:40:03.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-aberrant-protein-rewires-lymphoma-cells.html"
  },
  "original_language": "en",
  "account": "Scientists at Weill Cornell Medicine have uncovered a mechanism through which some lymphoma cells resist treatment with BTK inhibitors. This protein, BRG1, helps these cells survive by suppressing a deadly process called ferroptosis. By blocking BRG1, researchers found that BTK inhibitors become more effective, potentially offering a new treatment option for patients with B-cell cancers.",
  "summary": "A protein that can dial down oxidative stress in cells helps some cancers resist treatment with a widely used class of drugs called BTK inhibitors, according to a study led by investigators at Weill Cornell Medicine. The discovery points to a possible solution to the problem of BTK inhibitor treatment resistance.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}