{
  "id": 14631805,
  "title": "Early-life human lymphopoiesis generates a distinct B-cell lineage",
  "url": "https://urgent.news/2026/10/14/early-life-human-lymphopoiesis-generates-a-distinct-b-cell-lineage",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.07.756737v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "We characterize the first wave of human B-lymphopoiesis across gestation (n=42 donors) and identify a developmentally and functionally distinct B-cell lineage that shapes antibody specificity before birth. The earliest lymphoid progenitors engage an evolutionarily conserved genetic program enriched for imprinted genes associated with embryogenesis in mice and humans. These progenitors arise in…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}