{
  "id": 14610497,
  "title": "AAV-Mediated Ribozyme Targeting of HSV-1 Latency-Associated Transcript RNAs Reveals Distinct Functions of the LAT Intron and Exon In Vivo",
  "url": "https://urgent.news/2026/10/14/aav-mediated-ribozyme-targeting-of-hsv-1-latency-associated",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758874v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Herpes Simplex Virus 1 (HSV-1) establishes lifelong latency in sensory neurons of the trigeminal ganglia (TG), from which periodic reactivation causes recurrent disease. The latency-associated transcript (LAT) has been implicated in latency establishment, neuronal survival, and reactivation; however, most functional studies have relied on viral deletion mutants that alter genomic architecture and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}