{
  "id": 14457117,
  "title": "Generative design of functional disordered regions in a developmental transcription factor",
  "url": "https://urgent.news/2026/10/14/generative-design-of-functional-disordered-regions-in-a-developmental",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.757977v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Rapid advances in protein structure design have not translated to intrinsically disordered regions (IDRs). This is largely due to our incomplete understanding of how IDR sequence encodes function. Here, we use stem cell differentiation as a model to map functional sequence features in the IDR of transcription factor RUNX2. We show that RUNX2 requires its C-terminal IDR to bind chromatin and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}