{
  "id": 14457115,
  "title": "Temporal RNA splicing dysregulation in a human multicellular model of C9orf72 ALS",
  "url": "https://urgent.news/2026/10/14/temporal-rna-splicing-dysregulation-in-a-human-multicellular-model-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.755334v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Amyotrophic lateral sclerosis (ALS) is a complex and heterogenous disease, comprising of familial and sporadic forms, numerous genetic mutations, and a wide range of affected cell types and proposed dysregulated processes. While the usage of in vitro cell cultures, mouse models, and postmortem patient tissue have advanced our understanding of ALS disease mechanisms, the temporal progression of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}