{
  "id": 14457112,
  "title": "Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer's disease",
  "url": "https://urgent.news/2026/10/14/endothelial-cd36-links-arteriolar-remodeling-to-metabolic-and-immune",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758947v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Alzheimer's disease (AD) is accompanied by profound cerebrovascular dysfunction, yet it remains unclear whether endothelial abnormalities reflect only vascular injury or altered regulatory states connecting vascular remodeling with metabolic and immune function. We integrated human brain transcriptomic and histopathological data with complementary mouse genetic and human iPSC-derived endothelial…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 5,
    "also_reported_by": [
      {
        "outlet": "Science News",
        "title": "Scarred blood vessels may be one clue to APOE4’s Alzheimer’s risk",
        "url": "https://urgent.news/2026/10/12/scarred-blood-vessels-may-be-one-clue-to-apoe4s-alzheimers-risk",
        "published": "2026-10-12T16:00:00.000Z"
      },
      {
        "outlet": "Medical Xpress",
        "title": "Study offers new clues about how genetic risk for Alzheimer's affects brain immune cells",
        "url": "https://urgent.news/2026/10/12/study-offers-new-clues-about-how-genetic-risk-for-alzheimers-affects",
        "published": "2026-10-12T18:00:01.000Z"
      },
      {
        "outlet": "ETHealthworld",
        "title": "Early-onset Alzheimer's disease looks very different to late-onset version: Study",
        "url": "https://urgent.news/2026/10/13/early-onset-alzheimers-disease-looks-very-different-to-late-onset",
        "published": "2026-10-13T11:27:22.000Z"
      },
      {
        "outlet": "Endpoints News",
        "title": "Arrowhead’s brain-targeting RNA drug lowers Alzheimer’s protein in early study",
        "url": "https://urgent.news/2026/10/14/arrowheads-brain-targeting-rna-drug-lowers-alzheimers-protein-in",
        "published": "2026-10-14T11:30:27.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}