{
  "id": 14457110,
  "title": "An ER Retrieval-and-Release System Reveals Ligand-Independent Basal Signaling by Cell Surface TCRs",
  "url": "https://urgent.news/2026/10/14/an-er-retrieval-and-release-system-reveals-ligand-independent-basal",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758962v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The T cell receptor (TCR) machinery comprises the ligand-binding TCR{beta} and the CD3 signaling dimers. Individual subunits are synthesized in the endoplasmic reticulum (ER) and only the fully assembled TCRs reach the cell surface. We engineered a system to retained CD3{varepsilon} is in the ER. This allowed only partial TCR assembly, while continuous retrieval of CD3{varepsilon} from the Golgi…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}