{
  "id": 14442059,
  "title": "Oncogenic ETS factors expressed from fusion genes utilize EWSR1 to associate with the paraspeckle and regulate transcription.",
  "url": "https://urgent.news/2026/10/14/oncogenic-ets-factors-expressed-from-fusion-genes-utilize-ewsr1-to",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758628v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "ETS family transcription factors are aberrantly expressed in prostate cancer and Ewing sarcoma due to chromosomal rearrangements resulting in fusion genes, most commonly TMPRSS2::ERG and EWSR1::FLI1, respectively. The products of these gene fusions regulate transcription together with the intrinsically disordered protein EWSR1. However, the role of EWSR1 as a transcriptional co-regulator is not…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}