{
  "id": 14434562,
  "title": "Predicting resistance to synthetic lethal therapies in cancer",
  "url": "https://urgent.news/2026/10/14/predicting-resistance-to-synthetic-lethal-therapies-in-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.757986v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background Synthetic lethality (SL) occurs when an alteration in one gene renders cells vulnerable to inhibition of another, offering a strategy for targeted cancer therapy. PARP inhibitors represent the first clinically approved synthetic lethal therapy, and numerous additional candidates are now in clinical trials. Unfortunately, resistance to these therapies is common and impairs their overall…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}