{
  "id": 14427280,
  "title": "Biomarker-driven and gene-enhanced viral therapy for malignant peripheral nerve sheath tumor",
  "url": "https://urgent.news/2026/10/14/biomarker-driven-and-gene-enhanced-viral-therapy-for-malignant",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758653v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background: High-grade malignant peripheral nerve sheath tumors (MPNST) frequently lose Polycomb Repressive Complex 2 (PRC2), reducing the repressive histone mark, H3K27me3. We hypothesized that H3K27me3 loss sensitizes MPNST to oncolytic HSV due to impaired transcriptional resistance. HSV replication is also restricted by the integrated stress response, normally countered by HSV ICP34.5,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}