{
  "id": 14427279,
  "title": "A low-androgen environment sustains redox-active sGC states required to restrain castration-resistant prostate cancer growth via elevated cGMP levels",
  "url": "https://urgent.news/2026/10/14/a-low-androgen-environment-sustains-redox-active-sgc-states-required",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.753798v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Castration-resistant prostate cancer (CRPC) remains incurable and fatal, creating a dire need for new safe and effective treatment strategies. We recently reported that the soluble guanylyl cyclase (sGC) stimulator, riociguat, cooperates with standard-of-care androgen deprivation (AD) to inhibit castration-resistant tumor burden by oxygenating hypoxic tumor niches and inducing tumor apoptosis. We…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}