{
  "id": 14405340,
  "title": "Decoding super-enhancer regulatory grammar and pathogenic gain-of-function variants directly from DNA sequence",
  "url": "https://urgent.news/2026/10/14/decoding-super-enhancer-regulatory-grammar-and-pathogenic-gain-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.11.756618v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Super-enhancers (SEs) drive cell-identity gene expression, yet their identification relies on epigenomic profiling (e.g., H3K27ac ChIP-seq), precluding discovery in unprofiled cellular states and leaving their underlying sequence grammar unknown. Here, we present Borzoi-SE, a deep learning framework built upon the genomic transformer Borzoi that formulates SE discovery as hierarchical,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}