{
  "id": 14355863,
  "title": "Ontology-Driven Annotation of Key Events Enables Transcriptomics-Based Assessment of Adverse Outcome Pathway Networks",
  "url": "https://urgent.news/2026/10/13/ontology-driven-annotation-of-key-events-enables-transcriptomics",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756965v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Chemical safety assessment is moving towards new approach methodologies (NAMs) to improve human safety and reduce animal testing. The Adverse Outcome Pathway (AOP) is a NAM framework describing toxicity as a chain of Key Events (KEs). Many AOP-Wiki KEs describe molecular, cellular, or tissue-level processes and can therefore be assessed with gene expression data, making transcriptomics of human…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}