{
  "id": 14284519,
  "title": "Transient transcriptomic rejuvenation during intestinal and liver regeneration in mice",
  "url": "https://urgent.news/2026/10/13/transient-transcriptomic-rejuvenation-during-intestinal-and-liver",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.11.758291v1?rss=1"
  },
  "original_language": "en",
  "account": "The study explores the connection between aging and regeneration in mammals, specifically focusing on intestinal and liver regeneration. Researchers developed and validated transcriptomic aging clocks to measure tissue biological age, finding that epithelial states during regeneration are typically younger than control tissues. This younger state is associated with YAP-associated regeneration and reduced mature enterocyte identity.\n\nIn irradiation models, the predicted epithelial age initially increases, then decreases at the peak of regeneration, and rises again during recovery, with the pace of this response varying based on the host's age. Similarly, in chemotherapy-induced injury models, young animals exhibit a younger epithelial state earlier in recovery, which later returns to its preinjury state. Older epithelium responds later but also undergoes a reversible transition through a rejuvenated state.\n\nSpatial transcriptomic analyses further support these findings, linking lower epithelial age with regeneration in specific injured and tumor-associated regions. Additionally, liver regeneration after partial hepatectomy in old animals results in a decreased transcriptomic age, accompanied by pathways negatively associated with aging signatures. The study concludes that mammalian regeneration is associated with a transient reduction in biological age, whose timing and persistence depend on the tissue, host age, and the repair process.",
  "summary": "Aging and regeneration are fundamental biological processes, but the relationship between them is poorly understood. During intestinal regeneration, adult epithelial cells reactivate developmental programs that support repair. To investigate if this plasticity alters tissue biological age, we developed and validated intestinal tissue and epithelium-specific transcriptomic aging clocks. Across…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}