{
  "id": 14087551,
  "title": "Assessment of antimicrobial potential of cell-free supernatant from Lacticaseibacillus paracasei SRG isolated from the vaginal microbiota of healthy women against uropathogens",
  "url": "https://urgent.news/2026/10/12/assessment-of-antimicrobial-potential-of-cell-free-supernatant-from",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.11.758281v1?rss=1"
  },
  "original_language": "en",
  "account": "Urinary tract infections (UTIs) are a prevalent health issue among women, with around half of the adult female population experiencing at least one UTI episode. The increasing prevalence of antibiotic-resistant bacteria has complicated UTI treatment and management. Lactobacillus species, which are commonly found in urinary and vaginal microbiota and serve as probiotics, may offer a solution. In this study, researchers isolated Lacticaseibacillus paracasei SRG from the vaginal microbiota of healthy women and assessed its potential probiotic properties and antibacterial activity against eight uropathogens.\n\nThe antibacterial activity of L. paracasei SRG's cell-free supernatant (CFS) was found to be dependent on concentration and pH. The most effective concentrations were CFS/2 and CFS/4, along with acidic pH levels of 4 and 5. Notably, the antibacterial activity remained unchanged even after undergoing heat and proteinase K treatment, indicating the involvement of heat- and protease-resistant metabolites, in addition to acidic conditions.\n\nL. paracasei SRG demonstrated strong autoaggregation (85.32%) and cell-surface hydrophobicity (55.60%). Furthermore, it exhibited co-aggregation with all indicator strains, suggesting significant interaction with various pathogenic bacteria. These findings position L. paracasei SRG as a promising probiotic candidate derived from the indigenous vaginal microbiota.",
  "summary": "Among women, urinary tract infection (UTI) represents a major health concern. Approximately 50% of the adult female population experienced an episode of UTI at least once. UTI and recurrent UTIs caused by resistant bacteria are very common in clinical settings. The treatment and management of UTI is becoming more challenging because of the rise in antibiotic-resistant bacteria. Lactobacillus spp…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}