{
  "id": 14087548,
  "title": "Exploring recurrent urinary tract infection: paired microbiota and culture-based profiling reveals stable dysbiosis and multidrug-resistant, virulence-enriched uropathogens",
  "url": "https://urgent.news/2026/10/12/exploring-recurrent-urinary-tract-infection-paired-microbiota-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.10.758225v1?rss=1"
  },
  "original_language": "en",
  "account": "**Objective:** Researchers examined the urinary microbiome in women with recurrent urinary tract infections (rUTI) compared to healthy controls, investigating changes in bacterial composition, antibiotic resistance, and virulence factors.\n\n**Methods:** The study recruited 80 urine samples from women with untreated, treated, and prophylaxis rUTI, as well as age-matched healthy controls at four locations in South India. Of the collected samples, 75 were analyzed using 16S rRNA sequencing (V3-V4 region). Additionally, 105 culturable uropathogens were identified and tested for susceptibility to various antibiotics and assessed for virulence.\n\n**Results:** The rUTI groups exhibited lower alpha diversity compared to the healthy controls (median Shannon diversity index ranging from 1.07-1.18 vs 2.17; statistical significance, p = 0.041). Community structure exhibited significant differences between the rUTI groups and controls (PERMANOVA R-squared = 0.091, p = 0.004; pairwise false discovery rate = 0.008), but no differences existed among the individual rUTI subgroups. Notably, the relative abundance of Lactobacillus bacteria significantly decreased from 29.2% in healthy controls to lower levels in the rUTI groups.",
  "summary": "**Objectives:** Recurrent urinary tract infection (rUTI) is increasingly complicated by antimicrobial resistance (AMR), yet urinary microbiome dysbiosis and isolate-level resistance-virulence are rarely examined together across different treatment states. In this study, we characterized both within the same sample in rUTI and in healthy controls. **Methods:** In this cross-sectional cohort,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}