{
  "id": 13858633,
  "title": "Benchmarking interface confidence as a selection criterion for computational nanobody design against survivin's BIR-domain groove",
  "url": "https://urgent.news/2026/10/11/benchmarking-interface-confidence-as-a-selection-criterion-for",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.04.753929v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Designed binders are routinely filtered on predicted interface confidence, which reports how self-consistently a model places an interface, not where it lies. We designed 200 nanobody loops against the survivin BIR-domain groove, co-folded 196, and checked epitope contact in every predicted complex. Confidence showed no detectable association with epitope engagement ({rho} = +0.100, 95% CI -0.04…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}