{
  "id": 1321059,
  "title": "Gene-edited beagles produce no detectable major dog allergen, early tests find",
  "url": "https://urgent.news/2026/08/16/gene-edited-beagles-produce-no-detectable-major-dog-allergen-early",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-16T18:00:01.000Z",
  "source": {
    "name": "Phys.org",
    "slug": "phys-org",
    "url": "https://phys.org/news/2026-08-gene-beagles-major-dog-allergen.html"
  },
  "original_language": "en",
  "account": "Beagles genetically modified to produce no major dog allergen found in early tests, according to a study published in The CRISPR Journal. The research team used CRISPR-Cas9 technology to edit the Can f 1 gene, which is responsible for the protein found in dog saliva that triggers allergic reactions in humans. The edited DNA was introduced into mature eggs from donor beagles, resulting in two cloned female beagles named Alfie and Bailey. When tested, these gene-edited beagles showed no detectable trace of the Can f 1 allergen protein in their saliva, hair, and dander, unlike other dogs that were tested, including so-called hypoallergenic breeds. The researchers also conducted skin-prick tests on a volunteer with a known dog allergy, and found that the gene-edited beagles did not cause any allergic reaction, unlike the other dogs. However, the study acknowledges that further research is needed to establish the long-term safety, welfare, and efficacy of this genetic modification approach in dogs.",
  "summary": "Humans love dogs, but petting them can leave some people sneezing and wheezing. About 15% of the world's population lives with a dog allergy, which can increase the risk of hay fever and asthma. The main culprit is Can f 1, a protein found mainly in dog saliva. Right now, staying away from furry friends or getting regular immunotherapy shots or tablets is the only way to deal with the symptoms.",
  "key_points": [
    "Beagles genetically modified to produce no major dog allergen found in early tests",
    "Researchers used CRISPR-Cas9 technology to edit Can f 1 gene in beagle eggs",
    "Gene-edited beagles Alfie and Bailey showed no detectable Can f 1 allergen protein"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}