{
  "id": 13132620,
  "title": "Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities",
  "url": "https://urgent.news/2026/10/09/loss-of-the-y-chromosome-is-transcriptionally-silent-in-clear-cell",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-09T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757570v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Tumors in men often lose the Y chromosome. In some tumor types, this is predictive of poor outcome. Given the male predominance and high LOY frequency in clear cell renal cell carcinoma (ccRCC), we asked whether LOY might impact the transcriptome of ccRCC. We determined somatic Y chromosome status and performed differential expression analysis on tumor RNA-sequencing samples of two human ccRCC…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}