{
  "id": 13009590,
  "title": "Distinct metabolic states of yeast and pseudohyphae differentially prime innate immune responsiveness",
  "url": "https://urgent.news/2026/10/08/distinct-metabolic-states-of-yeast-and-pseudohyphae-differentially",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-08T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757614v1?rss=1"
  },
  "original_language": "en",
  "account": "Malassezia furfur, a type of skin-associated fungus, exhibits two distinct metabolic states: yeast and pseudohyphal. The yeast state maintains an active tryptophan-aldehyde metabolic program, dividing carbon between oxidative and reductive branches to maintain redox balance and methylation potential. In contrast, the pseudohyphal state undergoes sequential metabolic remodeling, beginning with changes in one-carbon and amino acid metabolism, followed by sulfur-pathway remodeling and increased glutathione biosynthesis.\n\nThese metabolic differences create separate extracellular environments for each state. When exposed to THP-1 cells, which are innate immune cells, yeast-conditioned cells produced extracellular cues that favored tissue-repair signals, while pseudohyphal-conditioned cells generated extracellular cues that promoted inflammatory stimuli. No single metabolite alone could account for these immune conditioning effects, indicating that the integrated extracellular milieu plays a crucial role.\n\nThe researchers conclude that pseudohyphal growth is an organized adaptive metabolic state, and that the fungal morphogenetic potential can influence context-dependent host immune responses. This work sheds light on the relationship between fungal morphology and host immunity, showing that the morphological change of pseudohyphae is not merely a morphological response, but also a metabolic reprogramming that primes the host's immune system differently than the yeast state.",
  "summary": "Pseudohyphal growth in skin-associated fungi is often considered a morphological response to environmental stress, but whether it represents a coordinated metabolic state that influences host immunity remains unclear. Using Malassezia furfur, we combined synchronized morphogenesis, temporal metabolomics, stable-isotope tracing, targeted metabolite measurements, transcriptional profiling, and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}