{
  "id": 12924674,
  "title": "Hyponatremia risk may differ across second-generation antipsychotics",
  "url": "https://urgent.news/2026/10/08/hyponatremia-risk-may-differ-across-second-generation-antipsychotics",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-08T18:20:01.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-hyponatremia-differ-generation-antipsychotics.html"
  },
  "original_language": "en",
  "account": "An analysis of hyponatremia risk associated with second-generation antipsychotic medications revealed potential differences among individual drugs. Associate Professor Masakazu Hatano and colleagues from Fujita Health University School of Medicine in Japan conducted a two-part study, first using FDA Adverse Event Reporting System data to generate hypotheses regarding hyponatremia risk, then evaluating these hypotheses using Japanese hospital-based claims data. The U.S. safety reporting analysis included 17.8 million reports, of which 458,745 involved second-generation antipsychotic monotherapy. Several drugs showed lower reporting odds for hyponatremia than olanzapine, the reference antipsychotic, with brexpiprazole and lurasidone showing the lowest reporting odds. However, these findings were hypothesis-generating due to limitations in the spontaneous reporting data. The Japanese claims database analysis included 55,394 patients prescribed antipsychotics, followed for up to 180 days. During follow-up, hyponatremia occurred in 366 patients (0.7%). After adjusting for differences in baseline characteristics and other factors, aripiprazole was associated with a significantly lower risk of hyponatremia compared to olanzapine, while other second-generation antipsychotics showed no significant differences. These findings suggest that the risk of hyponatremia may vary among individual second-generation antipsychotics, potentially guiding treatment decisions for patients at higher risk. However, the study's observational nature means residual confounding and differences in hyponatremia detection may have influenced the results.",
  "summary": "Antipsychotics are used to treat schizophrenia, along with bipolar disorder and major depressive disorder. However, these medications can be associated with hyponatremia, a serious reduction in blood sodium levels.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}