{
  "id": 128854,
  "title": "Scientists identify promising new target behind treatment resistance in advanced breast cancer",
  "url": "https://urgent.news/2026/08/04/scientists-identify-promising-new-target-behind-treatment-resistance",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-04T12:00:05.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-scientists-treatment-resistance-advanced-breast.html"
  },
  "original_language": "en",
  "account": "A recent study led by Houston Methodist researchers has uncovered a promising new target behind treatment resistance in advanced breast cancer. The study, published in Clinical Cancer Research, reveals that S100–RAGE signaling, a pathway crucial for cancer cells' survival, growth, adaptation to stress, and resistance to treatment, plays a key role in early drug resistance. Co-led by Stephen Wong, the research analyzed 47 patients and 109 metastatic lesions treated with trastuzumab deruxtecan (T-DXd), a common early-stage treatment for metastatic breast cancer. The findings suggest that blocking this signaling pathway makes cancer cells sensitive to early-line treatment, significantly reducing metastatic lesion number, size, and overall tumor burden in metastatic lab models. This discovery could pave the way for therapeutic options to target this pathway and improve treatment outcomes for patients with metastatic breast cancer, which has the lowest survival rate among women.",
  "summary": "A new Houston Methodist-led study published in Clinical Cancer Research reports a breakthrough in understanding why some patients with metastatic breast cancer fail to respond to a common and important early-stage treatment.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Medical Xpress",
        "title": "Scientists map dormant cancer cells' hideouts, opening new targets for treatment",
        "url": "https://urgent.news/2026/08/02/scientists-map-dormant-cancer-cells-hideouts-opening-new-targets-for",
        "published": "2026-08-02T14:00:01.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}