{
  "id": 12634076,
  "title": "Stoichiometry-dependent gating and structural pharmacology of cardiac GIRK1/4 channels",
  "url": "https://urgent.news/2026/10/07/stoichiometry-dependent-gating-and-structural-pharmacology-of-cardiac",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-07T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756879v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Cardiac G protein-gated inwardly rectifying potassium-K+ (GIRK) channels, formed by GIRK1/4 heterotetramers or GIRK4 homotetramers, are crucial regulators of heart rate, and their dysfunction is associated with atrial fibrillation. Despite their therapeutic potential as anti-arrhythmic targets, development of selective GIRK modulators has been limited by an incomplete understanding of their…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}