{
  "id": 12582230,
  "title": "\"Double-dipping\" in testing for phenotypic differences with scRNA-Seq",
  "url": "https://urgent.news/2026/10/06/double-dipping-in-testing-for-phenotypic-differences-with-scrna-seq",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.02.756269v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "For the purpose of differential expression (DE) analysis in single-cell RNA-sequencing (scRNA-Seq), phenotype differences between samples are often tested within specific cell types. Cell types are regularly imputed by clustering the same gene expression data which is later used for phenotype testing. This creates the potential for a \"double-dipping\" or post-selection inference problem resulting…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}