{
  "id": 12582218,
  "title": "Vac8-driven vacuolar remodeling primes mega-autophagy and safeguardsgamete developmental competence",
  "url": "https://urgent.news/2026/10/07/vac8-driven-vacuolar-remodeling-primes-mega-autophagy-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-07T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756849v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "During gametogenesis, organelle remodeling is coordinated alongside chromosome segregation to ensure gamete quality. In Saccharomyces cerevisiae, the precursor-cell vacuole permeabilizes following completion of meiotic divisions, releasing hydrolytic enzymes that degrade cellular material excluded from gametes. The regulation and biological significance of this developmentally-programmed process,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}